Article
PIKing the type and pattern of PI3K pathway mutations in endometrioid endometrial carcinomas.
Gynecologic oncology - 1 May 2015
Marchiò Caterina, De Filippo Maria R, Ng Charlotte K Y, Piscuoglio Salvatore, Soslow Robert A, Reis-Filho Jorge S, Weigelt Britta
Abstract excerpt
OBJECTIVE: The vast majority of endometrioid endometrial carcinomas (EECs) harbor mutations in the PI3K pathway. Here we sought to determine whether the type and pattern of mutations targeting different components of the PI3K pathway are distinct between microsatellite stable (MSS) and high-level microsatellite instable (MSI-H) EECs. METHODS: Whole exome massively parallel sequencing-based mutation data from EECs...
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