Article
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
Cancer discovery - 1 Jul 2011
Cheung Lydia W T, Hennessy Bryan T, Li Jie, Yu Shuangxing, Myers Andrea P, Djordjevic Bojana, Lu Yiling, Stemke-Hale Katherine, Dyer Mary D, Zhang Fan, Ju Zhenlin, Cantley Lewis C, Scherer Steven E, Liang Han, Lu Karen H, Broaddus Russell R, Mills Gordon B
Abstract excerpt
We demonstrate that phosphatidylinositol 3-kinase (PI3K) pathway aberrations occur in >80% of endometrioid endometrial cancers, with coordinate mutations of multiple PI3K pathway members being more common than predicted by chance. PIK3R1 (p85α) mutations occur at a higher rate in endometrial cancer than in any other tumor lineage, and PIK3R2 (p85β), not previously demonstrated to be a cancer gene, is also...
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