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Article

PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer.

Cancer research - 15 Jun 2011

Urick Mary E, Rudd Meghan L, Godwin Andrew K, Sgroi Dennis, Merino Maria, Bell Daphne W

Abstract excerpt

Phosphoinositide 3-kinase (PI3K) is an important therapeutic target. Mutations in PIK3CA, which encodes p110α, the catalytic subunit of PI3K, occur in endometrioid endometrial cancers (EEC) and nonendometrioid endometrial cancers (NEEC). The goal of this study was to determine whether PIK3R1, which encodes p85α, the inhibitory subunit of PI3K, is mutated in endometrial carcinoma. We carried out exonic sequencing...

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Share to Carcinoma, Endometrioid
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Endometrial Neoplasms

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 21478295
DOI: 10.1158/0008-5472.CAN-11-0549
PMCID: PMC3117071

Genes

KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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