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Article

Rare mutations in the PIK3CA gene contribute to aggressive endometrial cancer.

DNA and cell biology - 1 Feb 2010

Konstantinova Darina, Kaneva Radka, Dimitrov Roumen, Savov Alexey, Ivanov Stephan, Dyankova Tzvetanka, Kremensky Ivo, Mitev Vanio

Abstract excerpt

The molecular basis of endometrial cancer (EC), a common gynecologic malignancy, often includes mutational activation of the PIK3CA and KRAS genes. We aimed to determine the distribution of mutations in the two genes depending on patient clinocopathological characteristics. We sequenced exon 1 of the KRAS gene and exons 9 and 20 of the PIK3CA gene in 108 consecutive EC tumor samples. PIK3CA mutations were present...

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Identifiers

PMID: 19839777
DOI: 10.1089/dna.2009.0939

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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