Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma.

Cancer research - 1 Dec 2005

Oda Katsutoshi, Stokoe David, Taketani Yuji, McCormick Frank

Abstract excerpt

The phosphatidylinositol 3'-kinase (PI3K) pathway is activated in many human cancers. In addition to inactivation of the PTEN tumor suppressor gene, mutations or amplifications of the catalytic subunit alpha of PI3K (PIK3CA) have been reported. However, the coexistence of mutations in these two genes seems exceedingly rare. As PTEN mutations occur at high frequency in endometrial carcinoma, we screened 66 primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Gene Dosage

Share to Phosphatidylinositol 3-Kinases

Share to PTEN Phosphohydrolase

Share to RNA, Small Interfering

Share to Transfection

Source

Identifiers

PMID: 16322209
DOI: 10.1158/0008-5472.CAN-05-2620

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma.PMID 16322209Read ↗

PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia.Semantic proximity Read ↗

Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma.Semantic proximity Read ↗

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.Semantic proximity Read ↗

PIK3CA mutations and amplification in endometrioid endometrial carcinomas: relation to other genetic defects and clinicopathologic status of the tumors.Semantic proximity Read ↗

Mutual exclusiveness between PIK3CA and KRAS mutations in endometrial carcinoma.Semantic proximity Read ↗

Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis.Semantic proximity Read ↗

Somatic mutations are present in all members of the AKT family in endometrial carcinomaSemantic proximity Read ↗

PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer.Semantic proximity Read ↗

PIKing the type and pattern of PI3K pathway mutations in endometrioid endometrial carcinomas.Semantic proximity Read ↗

Pilot investigation of the mutation profile of PIK3CA/PTEN genes (PI3K pathway) in grade 3 endometrial cancerSemantic proximity Read ↗

Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.Semantic proximity Read ↗

PIK3CA alterations in Middle Eastern ovarian cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.