Article
Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 1995
Francis-West P H, Robertson K E, Ede D A, Rodriguez C, Izpisúa-Belmonte J C, Houston B, Burt D W, Gribbin C, Brickell P M, Tickle C
Abstract excerpt
The chicken mutant talpid3 (ta3) has polydactylous limbs with up to 7-8 morphologically similar digits. This lack of antero-posterior polarity in digit pattern is correlated with symmetrical expression of genes of the HoxD complex. We determined the distribution of polarizing activity in limb buds of the chick mutant ta3 by assessing the ability of mesenchyme from various positions along the antero-posterior axis...
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