Article
Multiple sclerosis immunopathic trait and HLA-DR(2)15 as independent risk factors in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 May 2007
Callander M, Haghighi S, Landtblom A-M, Ahlgren C E, Nilsson S I, Rydberg L, Al Khoury H, Rosegren L, Andersen O
Abstract excerpt
We analysed HLA haplotypes in pairs of 78 sporadic multiple sclerosis (MS) patients and 78 healthy siblings. The presence of 2 oligoclonal IgG bands, detected by immunoblotting of the cerebrospinal fluid in healthy siblings, has previously been defined as MS immunopathic trait (MSIT), based on a cut-off derived from healthy unrelated volunteers. The frequency of MSIT was 17.9% (n=14/78 siblings). The HLA-DR(15)2...
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