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Article

Viral Alteration of Cellular Translational Machinery Increases Defective Ribosomal Products

26 Apr 2007

Abstract excerpt

Here we show that cells expressing genes inserted into Semliki Forest virus (SFV) vectors generate a large fraction of defective ribosomal products (DRiPs) due to frequent initiation on downstream Met residues. In monopolizing the host cell translational machinery, SFV reduces levels of translation eukaryotic initiation factor 4E (eIF4E), diminishes phosphorylation of ribosome subunit S6, and phosphorylates...

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PMID: 17459927
DOI: 10.1128/jvi.00137-07

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