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Article

Overlapping signals for translational regulation and packaging of influenza A virus segment 2.

Nucleic acids research - 1 Sept 2011

Wise Helen M, Barbezange Cyril, Jagger Brett W, Dalton Rosa M, Gog Julia R, Curran Martin D, Taubenberger Jeffery K, Anderson Emma C, Digard Paul

Abstract excerpt

Influenza A virus segment 2 mRNA expresses three polypeptides: PB1, PB1-F2 and PB1-N40, from AUGs 1, 4 and 5 respectively. Two short open reading frames (sORFs) initiated by AUGs 2 and 3 are also present. To understand translational regulation in this system, we systematically mutated AUGs 1-4 and monitored polypeptide synthesis from plasmids and recombinant viruses. This identified sORF2 as a key regulatory...

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Identifiers

PMID: 21693560
DOI: 10.1093/nar/gkr487
PMCID: PMC3177217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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