Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells

Abstract excerpt

Mitosis is a critical phase of the cell cycle and a vulnerable point where cancer cells can be effectively disrupted, leading to cell death and inhibition of tumor growth. However, challenges such as drug resistance remain significant in clinical applications. During mitosis, mRNA translation is generally downregulated, while non-canonical translation of specific transcripts proceeds. Here, we demonstrate that mit...

Topics

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• Bacteriophages and microbial interactions
• CAR-T cell therapy research
• Immunotherapy and Immune Responses
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• RNA modifications and cancer
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

bae00f6c-d48f-576e-99bf-0766f5cbb08b

DOI

10.1101/2025.01.08.631915