Article
Role of the 5' --> 3' exonuclease and Klenow fragment of Escherichia coli DNA polymerase I in base mismatch repair.
Molecular genetics and genomics : MGG - 1 Aug 2007
Imai Masaru, Tago Yu-ichiro, Ihara Makoto, Kawata Masakado, Yamamoto Kazuo
Abstract excerpt
We have previously demonstrated that the Escherichia coli strain mutS DeltapolA had a higher rate of transition and minus frameshift mutations than mutS or DeltapolA strains. We argued that DNA polymerase I (PolI) corrects transition mismatches. PolI, encoded by the polA gene, possesses Klenow and 5' --> 3' exonuclease domains. In the present study, rates of mutation were found to be higher in Klenow-defective...
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