Article
The interaction of the Escherichia coli mutD and mutT pathways in the prevention of A:T-->C:G transversions.
Mutation research - 16 Dec 1992
Fowler R G, Amutan M V, Isbell R J
Abstract excerpt
The Escherichia coli mutT mutator allele produces high frequencies of exclusively A:T-->C:G transversions. This is thought to be caused by a failure to prevent or remove A:G mispairs during DNA replication. The mutD5 mutator allele maps to the dnaQ locus which encodes the epsilon subunit of the DNA polymerase III holoenzyme. This subunit provides 3'-->5' exonuclease, proofreading, activity for removing mispaired...
Topics
- Alleles
- DNA Polymerase III
- DNA Replication
- Escherichia coli
- Genes, Bacterial
- Point Mutation