Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Pol ε-dependent replication errors and the influence of mismatch repair on their correction.

DNA repair - 1 Nov 2013

Agbor Anderson Ayuk, Göksenin A Yasemin, LeCompte Kimberly G, Hans Samuel H, Pursell Zachary F

Abstract excerpt

Mutations in human DNA polymerase (Pol) ε, one of three eukaryotic Pols required for DNA replication, have recently been found associated with an ultramutator phenotype in tumors from somatic colorectal and endometrial cancers and in a familial colorectal cancer. Possibly, Pol ε mutations reduce the accuracy of DNA synthesis, thereby increasing the mutational burden and contributing to tumor development. To test...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mismatch Repair
Share to DNA Polymerase II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exonucleases

Share to HCT116 Cells

Share to Hypoxanthine Phosphoribosyltransferase

Share to Microsatellite Instability

Share to Mutation Rate

Share to Poly-ADP-Ribose Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24051051
DOI: 10.1016/j.dnarep.2013.08.012
PMCID: PMC4520434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Pol ε-dependent replication errors and the influence of mismatch repair on their correction.PMID 24051051Read ↗

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repairSemantic proximity Read ↗

A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading.Semantic proximity Read ↗

The high fidelity and unique error signature of human DNA polymerase epsilon.Semantic proximity Read ↗

Mutagenic mechanisms of cancer-associated DNA polymerase ε allelesSemantic proximity Read ↗

Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.Semantic proximity Read ↗

Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides.Semantic proximity Read ↗

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity.Semantic proximity Read ↗

A panoply of errors: polymerase proofreading domain mutations in cancer.Semantic proximity Read ↗

Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro.Semantic proximity Read ↗

Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells.Semantic proximity Read ↗

Replication-associated mechanisms contribute to an increased CpG > TpG mutation burden in mismatch repair-deficient cancers.Semantic proximity Read ↗

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.