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Article

Liver X receptor alpha associates with human life span.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2007

Mooijaart Simon P, Kuningas Maris, Westendorp Rudi G J, Houwing-Duistermaat Jeanine J, Slagboom P Eline, Rensen Patrick C N, van Heemst Diana

Abstract excerpt

In the nematode Caenorhabditis elegans, nuclear hormone receptor DAF-12 regulates the decision to go into a resistant dauer diapause, in which the worm exhibits a decreased rate of aging. Using sequence similarity searches, we previously identified the liver X receptor alpha (LXRalpha) as one of the human nuclear hormone receptors the protein sequence of which is most similar to C. elegans DAF-12. Here, we...

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Identifiers

PMID: 17452725
DOI: 10.1093/gerona/62.4.343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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