Article
Whole-genome microarray analysis identifies up-regulation of Nr4a nuclear receptors in muscle and liver from diet-restricted rats.
Mechanisms of ageing and development - 1 Apr 2009
Oita Radu C, Mazzatti Dawn J, Lim Fei Ling, Powell Jonathan R, Merry Brian J
Abstract excerpt
One of the most conserved methods to significantly increase lifespan in animals is through dietary restriction (DR). The mechanisms by which DR increases survival are controversial but are thought to include improvements in mitochondrial function concomitant with reductions in reactive oxygen species production and alterations in the insulin signalling pathway, resulting in global metabolic adaptation. In order...
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