Article
Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study.
Atherosclerosis - 1 May 2011
Legry Vanessa, Bokor Szilvia, Beghin Laurent, Galfo Myriam, Gonzalez-Gross Marcela, Molnar Denes, Moreno Luis A, Amouyel Philippe, Dallongeville Jean, Meirhaeghe Aline
Abstract excerpt
OBJECTIVE: Genetic variability in the NR1H3 gene (encoding LXRα) and in several of its target genes is associated with serum HDL-cholesterol (HDL-C) concentrations. We sought to assess if these associations could be detected in adolescents. METHODS: Thirty-nine polymorphisms in NR1H3, ABCA1, APOE, CETP, PLTP and LPL were analysed in the HELENA study (n = 1144 European adolescents). RESULTS: The minor alleles of...
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