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Article

Targeting liver X receptors in human health: deadlock or promising trail?

5 Jan 2011

Abstract excerpt

INTRODUCTION: Liver X receptors (LXR) are transcription factors that belong to the nuclear receptor superfamily. Natural derivatives of cholesterol, known as oxysterols, have been identified as agonistic ligands of LXR. They are thus mainly considered to be intracellular cholesterol 'sensors' whose activation leads to decreased plasma cholesterol. Their implication in other physiologic processes currently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21204733
DOI: 10.1517/14728222.2011.547853

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