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Article

Functional evolution of the pregnane X receptor.

Expert opinion on drug metabolism & toxicology - 1 Jun 2006

Iyer Manisha, Reschly Erica J, Krasowski Matthew D

Abstract excerpt

The pregnane X receptor (PXR; NR1I2) is a nuclear hormone receptor (NR) that transcriptionally regulates genes encoding transporters and drug-metabolising enzymes in the liver and intestine. PXR activation leads to enhanced metabolism and elimination of xenobiotics and endogenous compounds such as hormones and bile salts. Relative to other vertebrate NRs, PXR has the broadest specificity for ligand activators by...

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Identifiers

PMID: 16863441
DOI: 10.1517/17425255.2.3.381
PMCID: PMC2231407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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