Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe).

doi:10.1186/1471-2350-11-144

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Article

Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe).

BMC medical genetics - 12 Oct 2010

Solaas Karianne, Legry Vanessa, Retterstol Kjetil, Berg Paul R, Holven Kirsten B, Ferrières Jean, Amouyel Philippe, Lien Sigbjorn, Romeo Javier, Valtueña Jara, Widhalm Kurt, Ruiz Jonatan R, Dallongeville Jean, Tonstad Serena, Rootwelt Helge, Halvorsen Bente, Nenseter Marit S, Birkeland Kare I, Thorsby Per M, Meirhaeghe Aline, Nebb Hilde I

Abstract excerpt

BACKGROUND: The liver X receptors (LXR) α and β regulate lipid and carbohydrate homeostasis and inflammation. Lxrβ⁻/⁻ mice are glucose intolerant and at the same time lean. We aimed to assess the associations between single nucleotide polymorphisms (SNPs) in LXRβ and risk of type 2 diabetes mellitus (T2DM), obesity and related traits in 3 separate cohort studies. METHODS: Twenty LXRβ SNPs were identified by...

Topics

Adolescent
Adult
Aged
Alleles
Binding Sites
Cohort Studies
Diabetes Mellitus, Type 2
Europe
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

France

Genetic Predisposition to Disease

Genotype

Hepatocyte Nuclear Factor 4

Humans

Introns

Liver X Receptors

Male

Middle Aged

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Identifiers

PMID: 20939869
DOI: 10.1186/1471-2350-11-144
PMCID: PMC2958901

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