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Article

Screening for liver X receptor modulators: Where are we and for what use?

20 Oct 2020

Abstract excerpt

Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are canonically activated by oxidized derivatives of cholesterol. Since the mid-90s, numerous groups have identified LXRs as endocrine receptors that are involved in the regulation of various physiological functions. As a result, when their expression is genetically modified in mice, phenotypic analyses reveal endocrine disorders...

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PMID: 33080050
DOI: 10.1111/bph.15286

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