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Article

daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans.

Genes & development - 15 Jun 2000

Antebi A, Yeh W H, Tait D, Hedgecock E M, Riddle D L

Abstract excerpt

The daf-12 gene acts at the convergence of pathways regulating larval diapause, developmental age, and adult longevity in Caenorhabditis elegans. It encodes a nuclear receptor most closely related to two C. elegans receptors, NHR-8 and NHR-48, Drosophila DHR96, and vertebrate vitamin D and pregnane-X receptors. daf-12 has three predicted protein isoforms, two of which contain DNA- and ligand-binding domains, and...

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PMID: 10859169
PMCID: PMC316684

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