Article
Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic.
Chembiochem : a European journal of chemical biology - 7 May 2007
Baker James R, Woolfson Derek N, Muskett Frederick W, Stoneman Rhys G, Urbaniak Michael D, Caddick Stephen
Abstract excerpt
The enediyne chromoproteins are a class of potent antitumour antibiotics comprising a 1:1 complex of a protein and a noncovalently bound chromophore. The protein is required to protect and transport the highly labile chromophore, which acts as the cytotoxic component by reacting with DNA leading to strand cleavage. A derivative of the best-studied member of this class, neocarzinostatin (NCS), is currently in use...
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