Cloning and nucleotide sequencing of the antitumor antibiotic C-1027 apoprotein gene.

doi:10.1271/bbb.56.1592

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Article

Cloning and nucleotide sequencing of the antitumor antibiotic C-1027 apoprotein gene.

Bioscience, biotechnology, and biochemistry - 1 Oct 1992

Sakata N, Ikeno S, Hori M, Hamada M, Otani T

Abstract excerpt

The apoprotein gene for a chromoprotein antitumor antibiotic, C-1027, was cloned from the producer strain, Streptomyces globisporus C-1027, and sequenced. The process verified that; (1) the sequence included the entire structural gene directing a precursor of the apoprotein (pre-apoprotein having Met1---Ala33 leader peptide ahead of the apoprotein) and flanking regions, (2) the amino acid sequence of the...

Topics

Amino Acid Sequence
Aminoglycosides
Anti-Bacterial Agents
Antibiotics, Antineoplastic
Apoproteins
Base Sequence
Cloning, Molecular
DNA, Bacterial
Enediynes
Gene Expression
Genes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Proteins

Sequence Homology, Nucleic Acid

Streptomyces

Source

Open in PubMed

Identifiers

PMID: 1369059
DOI: 10.1271/bbb.56.1592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1369059-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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