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Article

Affinity transfer by CDR grafting on a nonimmunoglobulin scaffold

1 Jun 2004

Abstract excerpt

Neocarzinostatin (NCS) is a small "all beta" protein displaying the same overall fold as immunoglobulins. This protein possesses a well-defined hydrophobic core and two loops structurally equivalent to the CDR1 and CDR3 of immunoglobulins. NCS is the most studied member of the enediynechromoprotein family, and is clinically used as an antitumoral agent. NCS has promise as a drug delivery vehicle if new binding...

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PMID: 15169956
DOI: 10.1110/ps.03540504

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