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Article

Structural and energetic hot-spots for the interaction between a ladder-like polycyclic ether and the anti-ciguatoxin antibody 10C9Fab.

Molecular bioSystems - 1 Mar 2011

Ui Mihoko, Tanaka Yoshikazu, Tsumuraya Takeshi, Fujii Ikuo, Inoue Masayuki, Hirama Masahiro, Tsumoto Kouhei

Abstract excerpt

The mechanism by which anti-ciguatoxin antibody 10C9Fab recognizes a fragment of ciguatoxin CTX3C (CTX3C-ABCDE) was investigated by mutational analysis based on structural data. 10C9Fab has an extraordinarily large and deep antigen-binding pocket at the center of its variable region. We mutated s...

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Source

Identifiers

PMID: 21161086
DOI: 10.1039/c0mb00162g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21161086-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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