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Article

Onconase: an unusually stable protein.

Biochemistry - 1 Aug 2000

Notomista E, Catanzano F, Graziano G, Dal Piaz F, Barone G, D'Alessio G, Di Donato A

Abstract excerpt

Several members of the RNase A superfamily are endowed with antitumor activity, showing selective cytotoxicity toward tumor cell lines. One of these is onconase, the smallest member of the superfamily, which at present is undergoing phase-III clinical trials as an antitumor drug. Our investigation focused on other interesting features of the enzyme, such as its unusually high denaturation temperature, its low...

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Identifiers

PMID: 10913282
DOI: 10.1021/bi000415x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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