Article
Structure and Function of the Bacterial Protein Toxin Phenomycin.
Structure (London, England : 1993) - 5 May 2020
Hansen Bente K, Larsen Camilla K, Nielsen Jakob T, Svenningsen Esben B, Van Lan B, Jacobsen Kristian M, Bjerring Morten, Flygaard Rasmus K, Jenner Lasse B, Nejsum Lene N, Brodersen Ditlev E, Mulder Frans A A, Tørring Thomas, Poulsen Thomas B
Abstract excerpt
Phenomycin is a bacterial mini-protein of 89 amino acids discovered more than 50 years ago with toxicity in the nanomolar regime toward mammalian cells. The protein inhibits the function of the eukaryotic ribosome in cell-free systems and appears to target translation initiation. Several fundamental questions concerning the cellular activity of phenomycin, however, have remained unanswered. In this paper, we have...
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