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Article

Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Aug 2011

Ancín Inés, Cabranes José Antonio, Vázquez-Álvarez Blanca, Santos Jose Luis, Sánchez-Morla Eva, García-Jiménez María Ángeles, Fernández Cristina, Barabash Ana

Abstract excerpt

OBJECTIVES. Recent studies have evidenced that bipolar patients show a sensory gating deficit (P50). Among the neural systems that could be influencing this electrophysiological phenotype, dopamine seems to play an important role. We hypothesize that catechol-O-methyltransferase (COMT), the main metabolizer of dopamine in prefrontal cortex, is related to this deficit. METHODS. We selected three polymorphisms in...

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Source

Identifiers

PMID: 21595525
DOI: 10.3109/15622975.2011.552192

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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