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Article

Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors.

Neuroscience - 25 Jun 2013

de la Salle S, Smith D, Choueiry J, Impey D, Philippe T, Dort H, Millar A, Albert P, Knott V

Abstract excerpt

Elevated smoking rates seen in schizophrenia populations may be an attempt to correct neuropathologies associated with deficient nicotinic acetylcholine receptors and/or dopaminergic systems using exogenous nicotine. However, nicotine's effects on cognitive processing and sensory gating have been shown to be baseline-dependent. Evidence of a restorative effect on sensory gating deficits by nicotine-like agonists...

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Share to Catechol O-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evoked Potentials

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Source

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Identifiers

PMID: 23535252
DOI: 10.1016/j.neuroscience.2013.03.029
PMCID: PMC4534135

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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