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Article

Association of the G1947A COMT (Val(108/158)Met) gene polymorphism with prefrontal P300 during information processing.

Biological psychiatry - 1 Jul 2003

Gallinat Jürgen, Bajbouj Malek, Sander Thomas, Schlattmann Peter, Xu Ke, Ferro Erica F, Goldman David, Winterer Georg

Abstract excerpt

BACKGROUND: A common functional polymorphism, G1947A, of the catechol-O-methyltransferase (COMT) enzyme has gained interest in schizophrenia research because of its critical involvement in cortical dopamine catabolism and frontal lobe function. An assumed mechanism of dopamine is the reduction of noise in prefrontal neural networks during information processing. Therefore, the hypothesis was tested whether a...

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Source

Identifiers

PMID: 12842307
DOI: 10.1016/s0006-3223(02)01973-x

Genes

COMT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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