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Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?

27 Jan 2010

Abstract excerpt

BACKGROUND: Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype. METHOD: The...

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PMID: 20102668
DOI: 10.1017/s003329170999239x

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