Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating.

doi:10.1073/pnas.1118051109

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Article

Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating.

Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012

Quednow Boris B, Brinkmeyer Jürgen, Mobascher Arian, Nothnagel Michael, Musso Francesco, Gründer Gerhard, Savary Noah, Petrovsky Nadine, Frommann Ingo, Lennertz Leonhard, Spreckelmeyer Katja N, Wienker Thomas F, Dahmen Norbert, Thuerauf Norbert, Clepce Marion, Kiefer Falk, Majic Tomislav, Mössner Rainald, Maier Wolfgang, Gallinat Jürgen, Diaz-Lacava Amalia, Toliat Mohammad R, Thiele Holger, Nürnberg Peter, Wagner Michael, Winterer Georg

Abstract excerpt

Several polymorphisms of the transcription factor 4 (TCF4) have been shown to increase the risk for schizophrenia, particularly TCF4 rs9960767. This polymorphism is associated with impaired sensorimotor gating measured by prepulse inhibition--an established endophenotype of schizophrenia. We ther...

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PMID: 22451930
DOI: 10.1073/pnas.1118051109
PMCID: PMC3341057

Genes

TCF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22451930-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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