Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensorimotor gating of schizophrenia patients depends on Catechol O-methyltransferase Val158Met polymorphism.

Schizophrenia bulletin - 1 Mar 2010

Quednow Boris B, Wagner Michael, Mössner Rainald, Maier Wolfgang, Kühn Kai-Uwe

Abstract excerpt

It has been recently shown that Catechol O-methyltransferase (COMT) Val(158)Met polymorphism strongly influences prepulse inhibition (PPI) of the acoustic startle response (ASR) in healthy human volunteers. Given that schizophrenia patients exhibit impairment in PPI and that COMT is a putative susceptibility gene for schizophrenia, we investigated the impact of the COMT Val(158)Met polymorphisms on PPI in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Genetic Carrier Screening

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Habituation, Psychophysiologic

Share to Multifactorial Inheritance

Share to Polymorphism, Genetic

Share to Schizophrenia

Share to Schizophrenic Psychology

Share to Sensory Gating

Source

Open in PubMed Open full text

Identifiers

PMID: 18635674
DOI: 10.1093/schbul/sbn088
PMCID: PMC2833112

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensorimotor gating of schizophrenia patients depends on Catechol O-methyltransferase Val158Met polymorphism.PMID 18635674Read ↗

Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.Semantic proximity Read ↗

Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms.Semantic proximity Read ↗

The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers.Semantic proximity Read ↗

Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism.Semantic proximity Read ↗

Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.Semantic proximity Read ↗

The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males.Semantic proximity Read ↗

CHRNA4 was associated with prepulse inhibition of schizophrenia in Chinese: a pilot study.Semantic proximity Read ↗

Startle reactivity and prepulse inhibition of the acoustic startle response are modulated by catechol-O-methyl-transferase Val(158) Met polymorphism in adults with 22q11 deletion syndrome.Semantic proximity Read ↗

Association between genetic variability of neuronal nitric oxide synthase and sensorimotor gating in humans.Semantic proximity Read ↗

Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia.Semantic proximity Read ↗

Association of catechol-O-methyltransferase Val(108/158) Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population.Semantic proximity Read ↗

Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.