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Article

An association study between cathechol-O-methyltransferase gene and mental retardation in the Chinese Han population.

Neuroscience letters - 23 May 2007

Zhang Kejin, Gao Jianjun, An Caiyan, Gao Xiaocai, Zheng Zijian, Li Ruilin, Huang Shaoping, Zhang Fuchang

Abstract excerpt

Cathechol-O-methyltransferase (COMT) regulates the amount of dopamine in the prefrontal cortex (PFC). Substantial studies indicate a close relationship between COMT and several human psychotic disorders. The case-control method was used to study the association between mental retardation (MR) and genetic variants of COMT. Three single nucleotide polymorphisms (SNPs: rs4680, rs165656 and rs165774), in the...

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Source

Identifiers

PMID: 17442488
DOI: 10.1016/j.neulet.2007.03.050

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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