Article
No association of catechol-O-methyltransferase polymorphisms with schizophrenia in the Han Chinese population.
Genetic testing and molecular biomarkers - 1 Sept 2012
Zhang Fuquan, Liu Chenxing, Chen Yaguang, Wang Lifang, Lu Tianlan, Yan Hao, Ruan Yanyan, Yue Weihua, Zhang Dai
Abstract excerpt
AIMS: Genetics play a major role in the etiology of schizophrenia (SZ). Catechol-O-methyltransferase (COMT) is one of the promising candidate genes for SZ. A nonsynonymous single-nucleotide polymorphism (SNP), rs4680, causing a Valine (Val) to Methionine (Met) substitution, has been widely studied in relation to psychiatric phenotypes, including SZ, but with conflicting results. We conducted a two-stage study to...
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