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Roles of nonhomologous end-joining pathways in surviving topoisomerase II–mediated DNA damage

1 Jun 2006

Abstract excerpt

Topoisomerase II is a target for clinically active anticancer drugs. Drugs targeting these enzymes act by preventing the religation of enzyme-DNA covalent complexes leading to protein-DNA adducts that include single- and double-strand breaks. In mammalian cells, nonhomologous repair pathways are critical for repairing topoisomerase II-mediated DNA damage. Because topoisomerase II-targeting agents, such as...

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PMID: 16818498
DOI: 10.1158/1535-7163.mct-05-0263

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