Article
Relative contribution of homologous recombination and non-homologous end-joining to DNA double-strand break repair after oxidative stress in Saccharomyces cerevisiae.
DNA repair - 10 May 2006
Letavayová Lucia, Marková Eva, Hermanská Katarína, Vlcková Viera, Vlasáková Danusa, Chovanec Miroslav, Brozmanová Jela
Abstract excerpt
Oxidative damage to DNA seems to be an important factor in developing many human diseases including cancer. It involves base and sugar damage, base-free sites, DNA-protein cross-links and DNA single-strand (SSB) and double-strand (DSB) breaks. Oxidative DSB can be formed in various ways such as their direct induction by the drug or their generation either through attempted and aborted repair of primary DNA...
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