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Article

Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug Bleomycin

28 Mar 2025

Abstract excerpt

Abstract Background Bleomycin (Bleo) is a glycopeptide with potent antitumor activity that induces DNA double-strand breaks (DSBs) through free radical generation, similar to ionizing radiation (IR). Therefore, Bleo is considered a radiomimetic drug. However, differences in DNA repair mechanisms between IR- and Bleo-induced DNA damage have not been fully elucidated. Therefore, in the present study, we examined a...

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PMID: 40155951
DOI: 10.1186/s41021-025-00329-9

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