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Article

Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region

16 Apr 2007

Abstract excerpt

BACE1 is the protease responsible for the production of amyloid-beta peptides that accumulate in the brain of Alzheimer's disease (AD) patients. BACE1 expression is regulated at the transcriptional, as well as post-transcriptional level. Very high BACE1 mRNA levels have been observed in pancreas, but the protein and activity were found mainly in brain. An up-regulation of the protein has been described in some AD...

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PMID: 17439957
DOI: 10.1093/nar/gkm191

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