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Article

Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

31 Dec 2003

Abstract excerpt

Proteolytic processing of the beta-amyloid precursor protein (APP) at the beta site is essential to generate Abeta. BACE1, the major beta-secretase involved in cleaving APP, has been identified as a type 1 membrane-associated aspartyl protease. We have cloned a 2.1-kb fragment upstream of the human BACE1 gene and identified key regions necessary for promoter activity. BACE1 gene expression is controlled by a...

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PMID: 14701757
DOI: 10.1128/mcb.24.2.865-874.2004

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