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Article

Cloning and expression of the rat BACE1 promoter

9 May 2003

Abstract excerpt

The pathogenic processing of the amyloid precursor protein (APP) into beta-amyloid peptides, which give rise to beta-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BACE1). We report the cloning and sequence of a 1.5-kb DNA fragment upstream of the coding sequence of the rat BACE1 gene and the construction of a BACE1...

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PMID: 12815710
DOI: 10.1002/jnr.10639

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