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Regulation of β‐site APP‐cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease

28 Nov 2011

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to dementia. Neuritic plaques are the hallmark neuropathology in AD brains. Proteolytic processing of amyloid-β precursor protein at the β site by beta-site amyloid-β precursor protein-cleaving enzyme 1 (BACE1) is essential to generate Aβ, a central component of the neuritic plaques. BACE1 is increased in some sporadic AD brains, and...

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PMID: 22122349
DOI: 10.1111/j.1471-4159.2011.07515.x

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