Article
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.
EMBO reports - 1 Jun 2004
Lammich Sven, Schöbel Susanne, Zimmer Ann-Katrin, Lichtenthaler Stefan F, Haass Christian
Abstract excerpt
The aspartyl protease BACE1 has a pivotal role in the pathogenesis of Alzheimer's disease. Recently, it was shown that in Alzheimer's disease patients, BACE1 levels were elevated although mRNA levels were not changed compared with controls. Here, we demonstrate that the 5'-untranslated region (5'UTR) of BACE1 controls the rate of BACE1 translation. In the presence of the 5'UTR, we observed more than 90% reduction...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.