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Leaky Scanning and Reinitiation Regulate BACE1 Gene Expression

12 Apr 2006

Abstract excerpt

beta-Site beta-amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is the beta-secretase in vivo for processing APP to generate amyloid beta protein (Abeta). Abeta deposition in the brain is the hallmark of Alzheimer's disease (AD) neuropathology. Inhibition of BACE1 activity has major pharmaceutical potential for AD treatment. The expression of the BACE1 gene is relatively low in vivo. The control of BACE1...

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Identifiers

PMID: 16611980
DOI: 10.1128/mcb.26.9.3353-3364.2006

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