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Differential utilization of upstream AUGs in the β-secretase mRNA suggests that a shunting mechanism regulates translation

23 Feb 2004

Abstract excerpt

beta-Secretase [also known as the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1)] is an enzyme involved in the production of A beta-amyloid plaques in the brains of patients with Alzheimer's disease. The enhanced production of this enzyme occurs without corresponding changes in BACE1 mRNA levels. The complex 5' leader of BACE1 mRNA contains three upstream ORFs (uORFs) preceding the BACE1 initiation...

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PMID: 14981268
DOI: 10.1073/pnas.0308576101

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