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Article

Splice variants of the beta-site APP-cleaving enzyme BACE1 in human brain and pancreas.

Biochemical and biophysical research communications - 26 Apr 2002

Ehehalt Robert, Michel Beate, De Pietri Tonelli Davide, Zacchetti Daniele, Simons Kai, Keller Patrick

Abstract excerpt

BACE is the beta-secretase responsible for the first step in amyloidogenic processing of the amyloid precursor protein APP. We have identified two BACE isoforms, BACE1B and BACE1C, lacking 25 and 44 amino acids, respectively. Whereas the BACE1B transcript is present in human pancreas and brain, the BACE1C transcript is found in pancreas only. In transfected cells both BACE1A, which encodes the originally...

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Source

Identifiers

PMID: 12054559
DOI: 10.1016/S0006-291X(02)00169-9

Genes

APP
BACE1
BACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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