Dose Dependence of Emergence of Resistance to Linezolid inEnterococcus faecalisIn Vivo

Abstract excerpt

BACKGROUND: The emergence of resistance to antibiotics in vivo, particularly in commensal, potentially pathogenic bacteria, is a factor that is key to the future of antibiotics. To better document the circumstances favoring the emergence of resistance to linezolid (the first of a new class of antibiotics, the oxazolidinones), we modeled the effect of different regimens of linezolid on Enterococcus faecalis in...

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