Optimizing dosage to prevent emergence of resistance - lessons from in vitro models.

doi:10.1016/j.coph.2011.07.009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Optimizing dosage to prevent emergence of resistance - lessons from in vitro models.

Current opinion in pharmacology - 1 Oct 2011

Singh Renu, Tam Vincent H

Abstract excerpt

The widespread emergence of resistance to antimicrobial agents has taken mammoth dimension and warrants immediate steps to minimize it. Pharmacokinetics/pharmacodynamics of antimicrobial agents, differences among bacterial species, and time-dependent changes in the bacterial population are important factors involved in the development of drug resistance. The key to minimizing resistance lies in understanding how...

Topics

Animals
Anti-Bacterial Agents
Bacteria
Dose-Response Relationship, Drug
Drug Resistance, Bacterial
Humans
Models, Biological
Mutation
Time Factors

Source

Open in PubMed

Identifiers

PMID: 21868287
DOI: 10.1016/j.coph.2011.07.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics