Article
Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype.
Antimicrobial agents and chemotherapy - 1 Apr 2010
Ba Boubakar B, Arpin Corinne, Bikie Bi Nso Branly, Dubois Véronique, Saux Marie-Claude, Quentin Claudine
Abstract excerpt
The influence of antibiotic dosages and bacterial mutator phenotypes on the emergence of linezolid-resistant mutants was evaluated in an in vitro pharmacokinetic-pharmacodynamic model. A twice-daily 0.5-h infusion of a 200-, 600-, or 800-mg dose for 48 h was simulated against four strains (MIC, 2...
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