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Article

Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 May 2011

Ikeda-Dantsuji Yurika, Hanaki Hideaki, Nakae Taiji, Takesue Yoshio, Tomono Kazunori, Honda Junichi, Yanagihara Katsunori, Mikamo Hiroshige, Fukuchi Kunihiko, Kaku Mitsuo, Kohno Shigeru, Niki Yoshihito

Abstract excerpt

Methicillin-resistant Staphylococcus aureus with a MIC of linezolid of 4 μg/ml, isolated from a patient who had undergone unsuccessful linezolid therapy, yielded linezolid-resistant mutants in blood agar at 48 h of incubation. The resistant clones showed a MIC of linezolid ranging from 8 to 64 μg/ml and accumulated the T2500A mutation(s) of the rRNA genes. Emergence of these resistant clones appears to be...

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Identifiers

PMID: 21357291
DOI: 10.1128/AAC.01548-10
PMCID: PMC3088184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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